Medical Topic for Oswald

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Lynx
RESIST

Post   » Thu Dec 12, 2019 9:40 am


That's what I was thinking too. And why I asked about the bacteria found.

piggypatrol

Post   » Thu Dec 12, 2019 12:29 pm


I just sent you the pdf via email

piggypatrol

Post   » Thu Dec 12, 2019 1:19 pm


I just picked up his medication. Enronflocacin 22.7mg. She told me to crush about 1/2 a tablet into some food and syringe it to him every 12 hours

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Sef
Supporter in 2019

Post   » Thu Dec 12, 2019 1:55 pm


What is his weight?

piggypatrol

Post   » Thu Dec 12, 2019 1:57 pm


Today he was about 2.7 lbs

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Sef
Supporter in 2019

Post   » Thu Dec 12, 2019 2:18 pm


So, he weighs around 1.1kg. Half of a 22.7mg tablet would be 11.35 mg, which is a pretty high dose for his weight. With a standard range of roughly 2.5-10.0 mg/kg, a middle-of-the-road dose for his weight would be closer to 6.87mg. I think I'd be more inclined to quarter the tablet instead of cutting it in half, at least to start with to make sure it is well-tolerated. Just my opinion.

piggypatrol

Post   » Thu Dec 12, 2019 2:48 pm


Ok I had given him the half already but I will keep an eye on him and keep that in mind

User avatar
Lynx
RESIST

Post   » Thu Dec 12, 2019 3:06 pm


Here you go! Note the dangerous meds listed. Not prescribed, thankfully.


Culture Results: Status: FINAL

Isolate 1: Leclercia adecarboxylata - >100,000 CFU per ml

Generated by VetConnect® PLUS December 11, 2019 06:13 PM Page 3 of 4

DATE OF RESULT: 12/6/19 LAB ID: 7802569839
Microbiology (continued)

Isolate 2: Acinetobacter sp. - >100,000 CFU per ml
This isolate is considered an environmental or commensal organism, unlikely to be pathogenic in urine.
Therefore, susceptibility testing was not performed.
Isolate 1 MIC Isolate 2 MIC

Amoxicillin S <=2 N/I
Amoxicillin-Clavulanic Acid S <=2 N/I
Cephalexin S <=4 N/I
Cefpodoxime S 0.5 N/I
Cefovecin S <=0.5 N/I
Ceftazidime S <=0.12 N/I
Ceftiofur S <=1 N/I
Imipenem S <=0.25 N/I
Amikacin S <=2 N/I
Gentamicin S <=1 N/I
Ciprofloxacin S <=0.06 N/I
Enrofloxacin S <=0.12 N/I
Marbofloxacin S <=0.5 N/I
Doxycycline S 1 N/I
Nitrofurantoin S <=16 N/I
Chloramphenicol S <=2 N/I
Trimethoprim/Sulphate S <=20 N/I
Cefotaxime S N/I

**INTERPRETATION KEY for Antibiotic Susceptibility Results (when performed)**
S = Sensitive. Organism is inhibited by usual recommended dose.
I = Intermediate. Organism is inhibited only by the maximum recommended dose.
R = Resistant. Organism is resistant to the maximum recommended dose.

These standards have been established by the Clinical and Laboratory Standards Institute (CLSI).

TF = To Follow. Susceptibility testing for this antibiotic is performed by Kirby-Bauer and results will follow shortly.
N/I (not indicated) will be reported and/or MIC data may be left blank and not reported if:

a) the growth requirements of the organism require the sensitivity testing to be performed by another method
b) interpretive criteria are not available from CLSI (in this case, recommended antibiotics will be reported based on clinical efficacy studies)
c) certain antibiotics are not available due to limitations of our commercial laboratory system; or
d/ the drug is known to be clinically ineffective against the organism regardless of in vitro results

If "N/I" is listed for ALL antibiotics for a specific isolate, susceptibility testing was not performed for that organism. Please refer to the comment associated with the organism for recommendations if applicable.

For more information on Minimum Inhibitory Concentration (MIC) please see the "Microbiology Guide to Interpreting Minimum Inhibitory Concentration (MIC)" section of the IDEXX Reference Laboratories Directory of Services or visit www.idexx.com/MIC.

Sample appearance:
serum received unseparated or partially separated from cells.

Generated by VetConnect® PLUS December 11, 2019 06:13 PM

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Sef
Supporter in 2019

Post   » Thu Dec 12, 2019 3:26 pm


I'm not sure I understand the culture results. To this layperson's eye, it looks like that first "isolate" (Leclercia adecarboxylata) has sensitivity to all of those antibiotics -- including Bactrim:

Trimethoprim/Sulphate S <=20 N/I

Also, and even more confusing, I have not been able to find any literature on Leclercia adecarboxylata in guinea pigs or rabbits. Zilch. It doesn't even sound like it's very common in general. Did your vet remark on that at all?
It has been found only rarely in the environment or clinical isolates, and evidence of its involvement in causing disease is questioned.
https://www.vumicro.com/vumie/help/VUMICRO/Leclercia_adecarboxylata.htm
Leclercia adecarboxylata is a rare gram-negative rod of the Enterobacteriaceae family that has been isolated from water and infrequently reported in the literature.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544061/

piggypatrol

Post   » Thu Dec 12, 2019 4:17 pm


I don’t recall her mentioning that. It’s been about two hours since I gave him his dosage and he seems good he’s eating his hay and veggies and also gave him the benebac. Will check on him again after work

piggypatrol

Post   » Sat Dec 14, 2019 2:05 pm


Woke up this morning and no poops, found a few bits here and there. He ate his veggies last night but not much hay. I gave him so metoclopramide to see if that would help. While I was feeding him some CC he pooped on the towel but they weren’t well formed, I’m thinking maybe more benebac to counteract the antibiotic?

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Sef
Supporter in 2019

Post   » Sat Dec 14, 2019 2:12 pm


I would. I'm a bigger fan of just plain acidophilus, which you can mix with the Critical Care. We generally recommend probiotics at least an hour before or after giving an antibiotic, under the theory that it helps keep the "good" bacteria in the probiotic from getting wiped out by the antibiotic.

I'd contact the vet, but personally I'd be inclined to discontinue the Enrofloxacin. It doesn't sound like he is tolerating it very well.

piggypatrol

Post   » Sat Dec 14, 2019 2:24 pm


Unfortunately she’s not in on the weekend so I’d have to wait till Monday. Good thing is he didn’t lose weight

piggypatrol

Post   » Sat Dec 14, 2019 7:05 pm


I fed him some more CC before I left for work. I’ll check up on how he’s doing tonight and if it doesn’t look better I’ll reduce the amount of the antibiotic or just cut it completely. If things don’t improve I’ll take him back in on Monday

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Sef
Supporter in 2019

Post   » Sat Dec 14, 2019 9:13 pm


That sounds like a plan. At the very least, I would cut dose if you continue to see signs of gastric upset. Again, very high dose and that particular AB is not always well-tolerated.

Glad to hear that he hasn't lost weight. Do keep an eye on that.

piggypatrol

Post   » Sat Dec 14, 2019 9:29 pm


Yea I wanna make sure the infection does go down so I’ll cut the dosage and hopefully that will be a good balance. Thank you everyone, I’m just getting over a cold so it has been a mission but I love this little guy so I’d do anything for him.

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Sef
Supporter in 2019

Post   » Sat Dec 14, 2019 10:35 pm


No fun being sick!

piggypatrol

Post   » Mon Dec 16, 2019 12:40 pm


I ended up completely taking him off the antibiotic. He wasn’t pooping or eating on his own. He gets up and chews stuff and drink water but won’t eat hay. Been giving him CC and the metoclopramide but still no poop. Ate his lettuce last night but didn’t finish off the carrots. Weight this morning was the same. His dr isn’t in today but I made him an appointment for tomorrow.

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Sef
Supporter in 2019

Post   » Mon Dec 16, 2019 1:37 pm


Darn. Without looking back, can you remind me how you're dosing the Metoclopramide? Does the bottle mention what the concentration is? (certain amount of milligrams per ml). How often are you giving it to him?

piggypatrol

Post   » Mon Dec 16, 2019 2:24 pm


It’s 5mg/5ml I been giving him .5ml every 12 hours. I did 3 doses every 8 hours yesterday since I was home all day. I have noticed he’s been chewing on stuff a lot more I dunno if that has anything to do with it doc said his teeth looked fine during his last visit

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